The Cancer Genome Atlas Liver Hepatocellular Carcinoma (TCGA-LIHC) data collection is part of a larger effort to build a research community focused on connecting cancer phenotypes to genotypes by providing clinical images matched to subjects from The Cancer Genome Atlas (TCGA). Clinical, genetic, and pathological data resides in the Genomic Data Commons (GDC) Data Portal while the radiological data is stored on The Cancer Imaging Archive (TCIA).
Matched TCGA patient identifiers allow researchers to explore the TCGA/TCIA databases for correlations between tissue genotype, radiological phenotype and patient outcomes. Tissues for TCGA were collected from many sites all over the world in order to reach their accrual targets, usually around 500 specimens per cancer type. For this reason the image data sets are also extremely heterogeneous in terms of scanner modalities, manufacturers and acquisition protocols. In most cases the images were acquired as part of routine care and not as part of a controlled research study or clinical trial.
CIP TCGA Radiology Initiative
Imaging Source Site (ISS) Groups are being populated and governed by participants from institutions that have provided imaging data to the archive for a given cancer type. Modeled after TCGA analysis groups, ISS groups are given the opportunity to publish a marker paper for a given cancer type per the guidelines in the table above. This opportunity will generate increased participation in building these multi-institutional data sets as they become an open community resource. Learn more about the CIP TCGA Radiology Initiative.
Acknowledgements
We would like to acknowledge the individuals and institutions that have provided data for this collection:
Mayo Clinic, Rochester, MN - Special thanks to Bradley J. Erickson, M.D., Ph.D. from the Department of Radiology, Mayo Medical School.
University of North Carolina, Chapel Hill, NC - Special thanks to J. Keith Smith, M.D., Ph.D. and Shanah Kirk from the Department of Radiology, University of North Carolina School of Medicine.
Alberta Health Services, - Special thanks to Oliver Bathe, M.D., FRCS(C) from the Department of Oncology, and Melissa Kearns, MRT(R) CTIC.
Lahey Hospital & Medical Center, Burlington, MA - Special thanks to John Lemmerman, RT and Kimberly Reiger-Christ, PhD, Cancer Research, Sophia Gordon Cancer Center.
